Astronaut in the air

How to Read a Heavy Metals Test: What Blood, Urine and Hair Results Can and Can't Tell You

Eyal Barta •
#Heavy Metals#Lab Tests#Blood Test#Urine Test#Hair Analysis

Oregon’s public health FAQ says that heavy metals are all around us, so we are all expected to have some in our body. The same FAQ says the tests do not tell you if the metal is causing health effects. It explains how to read heavy metals blood test results line by line: the type of sample, the units, the reference range and the critical values. It also covers which other test types to treat with caution.

What your report actually measured

You can’t interpret the number until you know what sample it came from. Blood and urine are the most commonly used samples, according to MedlinePlus. Hair, fingernails, stool and organ tissue are also possible. Oregon’s FAQ adds that one single test is not going to give the best information for all heavy metals. Some metals are best measured in urine and some in blood.

A typical blood panel is the University of Michigan’s MLabs Heavy Metal Screen, which is sent out to the reference laboratory Mayo HMDB. It measures arsenic, cadmium, lead and mercury by Inductively Coupled Plasma/Mass Spectrometry. The lab lists its intended use as diagnosis of acute poisoning or toxicity.

Test typeWhat it can showWhat it can’t show
BloodAcute poisoning or toxicitySome metals already stored in tissues
Urine (unprovoked)Arsenic, inorganic mercury exposureWhether a metal causes effects
Provoked urineMetal pulled out by a chelatorHas no accepted standards
HairSuggests exposureAmount in body or disease

Step by step: reading the report

Check how the sample was collected. MLabs requires a royal blue top (trace element) tube with EDTA (K2), or Metal-Free aliquot tubes. The normal draw is 2.5 mL EDTA whole blood and the minimum is 0.3 mL. If you remember a standard tube being used, ask about it.

Rule out contrast dye. This one is easy to miss. MLabs says not to collect trace-metal samples from patients who have had gadolinium-, iodine-, or barium-containing contrast material within the past 96 hours, because these agents interfere with laboratory techniques. If you had a scan with contrast in the four days before your blood draw, tell your clinician.

Read the units before the number. One panel can mix units. Look at the table below. Compare each result only against the range on the same line, in the same units.

Compare against the lab’s own range. MLabs says plainly that reference ranges may change over time, and it tells readers to use the original patient report. Ranges from a website or another lab don’t apply to your result.

MetalReference range (as printed)CPT code
Arsenic<13 ng/mL82175
Lead<3.5 mcg/dL83655

Find the lead critical value for your age. MLabs flags lead as critical at 20 mcg/dL or above for ages 15 and under and at 70 mcg/dL or above for ages 16 and over.

Take both directions seriously. MedlinePlus says higher-than-normal levels may mean that you have heavy metal poisoning, but not always. Normal or low levels usually mean that you don’t. Even so, some metals leave the bloodstream quickly and are stored in tissues. If you still have symptoms, more testing may be needed.

Why a provoked urine number looks so high

You may have been offered a “challenge” or “provoked” urine test. In this test you first take a chelating drug, such as DMSA, DMPS, dimercaprol (BAL) or CaNa2-EDTA, and then collect urine. These drugs bind metals and increase their elimination from the body. That includes essential minerals such as zinc.

Because of how the test works, the urine level will always be higher than if you had not taken a chelator, Oregon’s FAQ explains. The result can give the impression that levels in your body are much higher than they actually are. The American College of Medical Toxicology (ACMT) wrote that scientifically acceptable normal reference values for post-challenge urine metal testing have not been established. Even so, some labs compare these results to normal, unprovoked ranges. The ACMT called that comparison inappropriate.

The ACMT’s position was blunt. It said post-challenge testing has not been scientifically validated, has no demonstrated benefit, and may be harmful. Valid urine testing is different. The ACMT considers it acceptable when the urine is collected before chelation, or a sufficiently long time after it (for example 3-5 days). Oregon’s FAQ also points readers to a federal notice titled FDA issues warnings to marketers of unapproved ‘chelation’ products, dated Oct. 14, 2010.

Hair analysis: exposure, not body burden

Hair readily picks up sweat and dust, so it is hard to tell if a metal is from inside or outside of the body. Shampoos, perm products, bleaches, and hair spray can all show up on a hair test. Oregon’s FAQ says a positive hair result cannot tell you anything about how much of the metal is in your body. It also says diagnosis or treatment should not be based on hair analysis alone.

Bring the report to your clinician

Diagnosis is more than one number. Oregon says diagnosing chronic heavy metal poisoning relies on having a known exposure and positive results on approved tests that are specific to each metal. Whether a metal is actually harming you must be determined in conversation with your health care provider. MedlinePlus says the same: talk with your provider to learn what your results mean.

Bring three questions to that appointment:

The clinician who reviews it with you should decide what happens next.

Sources

← Back to Blog